We are a computational science and engineering research group located at the Division of Scientific Computing at the Department of Information Technology, Uppsala University. With a core in scientific computing and systems biology, our mission is to develop next-generation tools for smart and efficient computational experimentation. A prominent application area is systems biology, where we seek to gain insight into spatial and temporal aspects of cellular regulatory systems. To that effect, we pursue a broad range of topics ranging from development of multiscale methods for spatial stochastic simulations to modeling of multicellular systems to cloud computing and development of smart and interactive computational science and engineering software. We are participating in the eSSENCE e-Science collaboration and the Computational Systems Biology (CSB) and Distributed Computing Applications (DCA) groups at the department of Information Technology.