The HASTE project, a SSF-funded project on computational science and big data, takes a holistic approach to new, intelligent ways of processing and managing very large amounts of microscopy images to leverage the imminent explosion of image data from modern experimental setups in the biosciences. One central idea is to represent datasets as intelligently formed and maintained information hierarchies, and to prioritize data acquisition and analysis to certain regions/sections of data based on automatically obtained metrics for usefulness and interestingness. The project is a collaboration between the Wählby lab (PI),  Hellander lab (co-PI), both at the Department of Information Technology, Uppsala University, the Spjuth lab (co-PI) at ...
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While we have learned a lot about gene regulation and control from single cell models, there is a limit to what can be understood without considering cell-cell interaction. However, there is a fundamental computational gap between detailed models of single cells and models of multicellular systems comprising of large number of interacting cells such as bacterial colonies, tissue and tumors. We seek to bridge the vast computational gap between quantitative, stochastic models of intracellular regulatory pathways and coarse-level models of multicellular systems. We also engage in development of simulation methodology for modeling specific biological systems toghether with collaborators. Recent publications: Marketa ...
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The integration between on the one hand data, modeling and algorithms, and on the other hand the specification, coordination and execution of large scale and data-intensive computational experiments poses a fundamental problem in all scientific disciplines relying on modeling and simulation. Today it is largely left to the modeler or engineer to manually tune models to fit data, to choose algorithms, to configure simulation workflows and to analyze simulation result. This is a big burden to place on e.g. a biologist who is mainly interested in how she can use modeling and simulation to learn new things about a biological ...
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Open source computational science and engineering (CSE) software is an integral part of methodology-oriented computational research and a priority in the group. Due to the ongoing transformation of e-infrastructure to clouds, methods and workflows that promote horizontal scalability and elasticity for cloud applications are needed, and this may in many cases require re-thinking of how we best make use of computational resources. Other important questions include reproducibility and handling of large and complex data.  Selected recent publications:  B. Drawert, A. Hellander, B. Bales, D. Banerjee, G. Bellesia, B.J. Daigle, Jr. G. Douglas, M. Gu, A. Gupta, S. Hellander, C. Horuk, D. Nath, ...
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A theme in the last decade of computational systems biology has been how molecular noise is a factor that needs to be acc ounted for, both to understand how gene regulatory networks are able to operate robustly in a noisy molecular environment and to explain phenotypic variability on both the individual cell and population levels. A particularly intriguing question is the interplay between spatial and temporal aspects of intracellular signaling is organized. Numerically, efficient spatial stochastic methods are needed to study this, but they become much more computationally demanding, largely due to the multiscale nature of the pathways and processes ...
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