Many biochemical network models display scale separation with respect to reaction rates and/or molecular copy numbers. Depending on the type of question under study, different models are best suited to simulate the system. For some parts of the system, a macroscopic model might be appropriate. For other parts, a mesoscopic model may provide additional insight into the models dynamics. In other cases, a microscopic model might be needed to capture the fine-grained features of the model. To efficiently simulate systems that have different requirements with respect to modeling levels, hybrid methods offer an attractive approach.